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And lastly, clonidine improves neuraxial opioids and, together with fentanyl, interacts in an additive way, which may reduce the dose of each and every ingredient by 60% for postoperative analgesia.Jun 10, 2024 · If clonidine therapy would be to get replaced by a β-blocker, delay administration from the β-blocker for several times soon after cl

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